1987-1993    中国药科大学，博士（导师：安登魁和相秉仁教授） 

1980-1984    南京药学院，学士 

工作经历： 

1997-        中国科学院上海有机化学研究所, 国家大型科学仪器中心上海有机质谱中心主任, 课题组组长, 研究员 

1993-1996    中国药科大学分析计算中心质谱色谱室主任，讲师 

研究领域： 

1. 新型有机质谱离子源研发和相关分析技术研究 

2. 质谱学研究过渡金属催化剂及其参与或催化的反应 

3. 活泼瞬态反应中间体和有机反应机理的质谱学研究 

4. 高效稳定同位素标记的衍生化试剂和反应的研发与应用 

代表论著： 

1. Zhang, J.-T.; Wang, H.-Y.; Zhang, X.; Zhang F.; Guo, Y.-L. Study of short-lived and early reaction intermediates in organocatalytic asymmetric amination reactions by ion-mobility mass spectrometry. Catal. Sci. Technol. 2016, 6, 6637 - 6643 

2. Yuan, Z.-L.; Wang, H.Y.; Mu, X.; Chen, P.-H.; Yin-long Guo, Y.-L.; Liu, G-S.. Highly Selective Pd-Catalyzed Intermolecular Fluorosulfonylation of Styrenes. J. Am. Chem. Soc. 2015, 137(7), 2468-2471. 

3. Liu, X.-P.; Wang, H.-Y.; Zhang, J.-T.; Wu, M.-X.; Qi, W.-S.; Zhu, H.; Guo, Y.-L. Direct and Convenient Mass Spectrometry Sampling with Ambient Flame Ionization. Sci. Rep. 2015, 5, 16893. 

4. Zhang, J.-T.; Wang, H.-Y.; Zhu, W.; Cai, T.-T.; Guo, Y.-L. Solvent-assisted Electrospray Ionization for Direct Analysis of Various Compounds (complex) from Low/non-polar Solvents and Eluents. Anal. Chem. 2014, 86(18), 8937–8942. 

5. Wang, H.-Y.; Zhao, Z.-X.; Guo Y.-L. Chemical and biochemical applications of MALDI TOF-MS based on analyzing the small organic compounds. Top. Curr. Chem. 2013, 331, 165-192. 

6. Mu, X.; Wu, T.; Wang, H.-Y.; Guo, Y.-L.; Liu, G.-S. Palladium-catalyzed oxidative aryltrifluoromethylation of activated alkenes at room temperature. J. Am. Chem. Soc. 2012, 134(2), 878-881. 

7. Xu, Z.; Wang, H.-Y.; Huang, S.-X.; Wei, Y. L.; Yao, S.-J.; Guo, Y.-L. Determination of β-Lactamases residues in milk using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry. Anal. Chem. 2010, 82(5), 2113–2118. 

8. Bao, H.-L.; Zhou, J.; Wang, Z.; Guo, Y.-L.; You, T.-P.; Ding, K.-L. Insight into the mechanism of the asymmetric ring-opening aminolysis of 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane catalyzed by titanium/BINOLate/water system: Evidence for the Ti(BINOLate)2-bearing active catalyst entities and the role of water. J. Am. Chem. Soc. 2008, 130, 10116-10127. 

9. Qian, R.; Guo, H.; Liao, Y.-X.; Guo, Y.-L.; Ma, S.-M. Probing the Mechanism of Palladium-Catalyzed Addition of Organoboronic Acids to Allenes in the Presence of AcOH with ESI-FTMS. Angew. Chem. Int. Ed. 2005, 44(30), 4771-4774. 

10. Guo, H.; Qian, R.; Liao, Y.-X.; Ma, S.-M.; Guo, Y.-L. ESI-MS Studies on the Mechanism of Pd(0)-Catalyzed Three-Component Tandem Double Addition-Cyclization Reaction. J. Am. Chem. Soc. 2005, 127(37), 13060-13064.